Final Research Progress Report by Xin Fan, PhD, and Morgan DiLeo, PhD

 Xin Fan, PhD, Investigator and Morgan DiLeo, PhD, Mentor, University of Pittsburgh, Pennsylvania

In the fall of 2022, CRF awarded this grant to Dr. DiLeo and her research fellow, Xin Fan, to investigate a sustained-release drug delivery mechanism to improve the treatment of ocular cystinosis, titled “Liposome cysteamine carriers for eye drop formulation with long-term stability and smart release ability.” Through this fellowship grant, the team at the University of Pittsburgh developed cysteamine-loaded liposomes with sustained drug release ability to last more than 24 hours. In Addition, the baseline liposome formulation can maintain 92% of the cysteamine after seven-day storage. This exciting work is paving the way to a better treatment for ocular cystinosis.

Read the final progress report and the lay abstract.