Researchers Francesco Emma, MD, Head Nephrology Unit, and Anna Taranta, PhD, Senior Research Associate, received grant funding in 2022 for their research on the “Impact of Diet Composition on Renal Function and Bone Disease of Ctns⁻/⁻ Mice.”
The Ctns-/- knock-out mouse model has been instrumental in the past years to increase our understanding of cystinosis and to develop new treatments. Recently, we have observed that a simple change in “standard diet” can modify substantially the severity of the disease in mice. This observation led them to hypothesize that differences in kidney and bone results between laboratories may be related to subtle differences in the composition of food that different animal facilities use. The purpose of this study is to understand which dietary components influence kidney and bone health to ensure homogeneity of results among other laboratories and to acquire new knowledge on the physiopathology of cystinosis. Download the full report.